References for Echinacea purpurea – Ech.f product – Hekma Center
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References for Echinacea purpurea – Ech.f product

References for Echinacea purpurea – Ech.f product

– Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamics interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin Pharmacol. 2010;69(5):508–515.

– Anonymous. Immunallergische Reaktionen nach Echinacea-Extracten (Echinacin, Esberitox N u.a. Arznei-Telegramm 1991.

– Ardjomand-Woelkart K, Kollroser M, Derendorf H, Bauer R, Butterweck V. Herb-drug interactions: effects of Echinacea preparations on cytochrome P450 activities in rats. Planta Med 2012; 78: PH10.

– Ardjomand-Woelkart K, Kollroser M, Li L, Derendorf H, Butterweck V, Bauer R. Development and validation of a LC MS/MS method based on a new 96-well HybridSPE™-precipitation technique for quantification of CYP450 substrates/metabolites in rat plasma. Anal Bioanal Chem 2011; 400: 2371–2381.

– Awortwe C, Manda VK, Avonto C, Khan SI, Khan IA, Walker LA, Bouic PJ, Rosenkranz B. Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway. Xenobiotica. 2015 Mar;45(3):218-29. Epub 2014 Nov 7.

– Barrett, B., Brown, R., Rakel, D., Mundt, M., Bone, K., Barlow, S., and Ewers, T. Echinacea for treating the common cold: a randomized trial. Ann.Intern.Med 12-21- 2010;153(12):769-777.

– Blumenthal M, et al., eds. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council; 1998. pp. 327–328, 391–393.

– Bodinet C, Lindequist U, Teuscher E, Freudenstein J. Effect of an orally applied herbal immunomodulator on cytokine induction and antibody response in normal and immunosuppressed mice. Phytomedicine 2002;9:606-613.

– Bone K. Echinacea: when should it be used? Mod Phytotherapist 1997;3:17-21.

– Bossaer JB, Odle BL. Probable etoposide interaction with Echinacea. J Diet Suppl. 2012 Jun;9(2):90-5.

– Bruynzeel DP, van Ketel WG, Young E, et al. Contact sensitization by alternative topical medicaments containing plant extracts. Cont. Derm., 27:278-279, 1992.

– Burger RA, Torres AR, Warren RP et al. Echinacea-induced cytokine production by human macrophages. Int J Immunopharmacol 1997;19:371-379.

– Coeugniet E, Kuhnast R. Adjuvant immunotherapy with different formulations of Echinacin. Therapiewoche, 1986, 36:3352-3358.

– Cohen, H. A., Varsano, I., Kahan, E., Sarrell, E. M., and Uziel, Y. Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study. Arch.Pediatr.Adolesc.Med. 2004;158(3):217-221.

– Currier NL, Miller SC. Natural killer cells from aging mice treated with extracts From Echinacea purpurea are quantitatively and functionally rejuvenated. Exp Gerontol 2000;35:627-639.

– Di Pierro F, Rapacioli G, Ferrara T, et al. Use of a standardized extract from Echinacea angustifolia (Polinacea®) for the prevention of respiratory tract infections. Altern. Med. Rev., 2012,17(1):36-41.

-Echinacea, in The Review of Natural Products. Edited by DerMarderosian A, Beutler JA. St. Louis, Missouri, Facts and Comparisons, 2000.

– Elsasser-Beile U, Willenbacher W, Bartsch HH et al. Cytokine production in leukocyte cultures during therapy with Echinacea extract. J Clin Lab Anal 1996;10:441-445.

– European Medicines Agency. Assessment Report on Echinacea purpurea (L.) Moench, herba recens. EMA/HMPC/557979/2013. London: European Medicines Agency; 2015.

– Gabranis I, Koufakis T, Papakrivos I, Batala S. Echinacea-associated acute cholestatic hepatitis. J Postgrad Med. 2015 Jul-Sep;61(3):211-2.

– German Federal Minister of Justice: German Commission E for human medicine monograph. Bundes–Anzeiger (German Federal Gazette), no. 162, dated 29.08.1992.

– Giles JT, Palat CT, 3rd, Chien SH, Chang ZG, Kennedy DT. Evaluation of echinacea for treatment of the common cold. Pharmacotherapy 2000;20:690-7.

– Goel V, Chang C, Slama J et al. Echinacea stimulates macrophage function in the lung and spleen of normal rats. J Nutr Biochem 2002;13:487.

– Goey AK1, Meijerman I, Rosing H, Burgers JA, Mergui-Roelvink M, Keessen M, Marchetti S, Beijnen JH, Schellens JH. The effect of Echinacea purpurea on the pharmacokinetics of docetaxel. Br J Clin Pharmacol. 2013 Sep;76(3):467-74.

– Gorski JC, Huang S-M, Pinto A et al. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther 2004;75:89-100.

– Grimm W, Muller HH. A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections. Am J Med 1999;106:138-43.

– Gurley BJ, Swain A, Hubbard MA, Williams DK, Barone GW, Hartsfield F, Tong Y, Carrier DJ, Cheboyina S, Battu SK. Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. Johnʼs wort, and Echinacea. Mol Nutr Food Res 2008; 52: 755–763.

– Heitmann K, Havnen GC, Holst L, Nordeng H. Pregnancy outcomes after prenatal exposure to echinacea: the Norwegian Mother and Child Cohort Study. Eur J Clin Pharmacol. 2016 May;72(5):623-30. Epub 2016 Feb 19.

– Huntley, A. L., Thompson, Coon J., and Ernst, E. The safety of herbal medicinal products derived from Echinacea species: a systematic review. Drug Saf 2005;28(5):387-400.

– Isbaniah, F., Wiyono, W. H., Yunus, F., Setiawati, A., Totzke, U., and Verbruggen, M. A.Echinacea purpurea along with zinc, selenium and vitamin C to alleviate exacerbations of chronic obstructive pulmonary disease: results from a randomized controlled trial. J Clin.Pharm.Ther 2011;36(5):568-576.

– Kemp DE, Franco KN. Possible leukopenia associated with long-term use of echinacea. J Am Board Fam Pract. 2002 Sep-Oct;15(5):417-9.

– Kocaman O, Hulagu S, Senturk O. Echinacea-induced severe acute hepatitis withfeatures of cholestatic autoimmune hepatitis. Eur. J. Int. Med., 2007.

– Lersch C, Zeuner M, Bauer A et al. Nonspecific immunostimulation with low doses of cyclophosphamide (LDCY), thymostimulin, and Echinacea purpurea extracts (Echinacin) in patients with far advanced colorectal cancers: preliminary results. Cancer Invest 1992;10:343-348.

– Lersch C, Zeuner M, Bauer A et al. Stimulation of the immune response in outpatients with hepatocellular carcinomas by low doses of cyclophosphamide (LDCY), Echinacea purpurea extracts (Echinacin) and thymostimulin. Arch Geschwulstforsch 1990;60:379-383.

– Liatsos G, Elefsiniotis I, Todorova R, et al. Severe thrombotic thrombocytopenic purpura(TTP) induced or exacerbated by the immunostimulatory herb Echinacea. Am J.Hematol., 2006,81:224.

– Logan JL, Ahmed J. Critical hypokalemic renal tubular acidosis due to Sjogren‟s syndrome: association with the purported immune stimulant echinaea. Clin. Rheumatol., 2003,22:158-159.

– Luettig B, Steinmuller C, Gifford GE et al. Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J Natl Cancer Inst 1989;81:669-675.

– Maskatia ZK, Baker K. Hypereosinophilia associated with echinacea use. South. Med. J., 2010,103(11):1173-1174.

– Melchart D, Clemm C, Weber B et al. Polysaccharides isolated from Echinacea purpureaherba cell cultures to counteract undesired effects of chemotherapy: a pilot study. Phytother Res 2002;16:138-142.

– Melchart D, et al. Immunomodulation with Echinacea – a systematic review of controlled clinical trials. Phytomedicine 1994.

– Miller SC. Echinacea: a miracle herb against aging and cancer? Evidence in vivo in mice. Evid Based Complement Altern Med 2005;2:309-314.

– Mills & Bone – Principles and practice of Phytotherapy. Modern Herbal Medicine,2ed. Churchill Livingstone, 2013.

– Modarai M, Gertsch JÜ, Suter A, Heinrich MM, Kortenkamp A. Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co-varies with alkylamide content. J Pharm Pharmacol 2007; 59.

– Modarai M, Yang M, Suter A, Kortenkamp A, Heinrich MM. Metabolomic profiling ofliquid Echinacea medicinal products with in vitro inhibitory effects on cytochrome P450. 3A4 (CYP3A4). Planta Med 2010; 76: 378–385.

-Moltó J, Valle M, Miranda C, Cedeño S, Negredo E, Clotet B. Herb-drug interaction between Echinacea purpurea and etravirine in HIV-infected patients. Antimicrob Agents Chemother. 2012 Oct;56(10):5328-31.

– Molto J, Valle M, Miranda C, et al. Herb-drug interaction between Echinacea purpurea and darunavir/ritonavir in HIV-infected patients. Antimicrob. Agents Chemother., 2011, 55(1):326-330.

– Mrozikiewicz PM, Bogacz A, Karasiewicz M, Mikołajczak PL, Ozarowski M, SeremakMrozikiewicz A, Czerny B, Bobkiewicz-Kozłowska T, Grze- śkowiak E. The effect of standardized Echinacea purpurea extract on rat cytochrome P450 expression level. Phytomedicine 2010; 17: 830– 833.

– Mullins RJ, Heddle R. Adverse reactions associated with Echinacea: the Australian experience. Ann. Allergy Asthma Immunol., 88:42-51, 2002.

– Neri PG, Stagni E, Filippello M, et al. Oral Echinacea purpurea extract in low-grade, steroid-dependent, autoimmune idiopathic uveitis: a pilot study. J. Ocular Pharm. Ther. 2006, 22(6):431-436.

– Parnham MJ. Benefit-risk assessment of the squeezed sap of the purple coneflower (Echinacea purpurea) for long-term oral immunostimulation. Phytomed., 3(1):95-102,1996.

– Perri D1, Dugoua JJ, Mills E, Koren G. Safety and efficacy of echinacea (Echinacea angustafolia, e. purpurea and e. pallida) during pregnancy and lactation. Can J Clin Pharmacol. 2006 Fall;13(3):e262-7.

– Randolph RK, Gellenbeck K, Stonebrook K et al. Regulation of human immune gene expression as influenced by a commercial blended Echinacea product: preliminary studies. Exp Biol Med (Maywood) 2003;228:1051-1056.

– Raner GM, Cornelious S, Moulick K, Wang Y, Mortenson AM, Cech NB. Effects of herbal products and their constituents on human cytochrome P4502E1 activity. Food Chem Toxicol 2007; 45: 2359–2365.

– Roesler J, Emmendorffer A, Steinmuller C et al. Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to test subjects mediates activation of the phagocyte system. Int J Immunopharmacol 1991;13:931-941.

– Schapowal, A., Berger, D., Klein, P., and Suter, A. Echinacea/sage or chlorhexidine/ lidocaine for treating acute sore throats: a randomized double-blind trial. Eur.J Med Res 9-1-2009;14(9):406-412.

– Schulten, B., Bulitta, M., Ballering-Bruhl, B., Koster, U., and Schafer, M. Efficacy of Echinacea purpurea in patients with a common cold. A placebo-controlled, randomised, double-blind clinical trial. Arzneimittelforschung. 2001;51(7):563-568.

– Schwarz E, Metzler J, Diedrich JP et al. Oral administration of freshly expressed juice of Echinacea purpurea herbs fail to stimulate the nonspecific immune response in healthy young men: results of a double-blind, placebo-controlled crossover study. J Immunother 2002;25:413-420.

– Scott R. Penzak et al. Echinacea Purpurea Significantly Induces Cytochrome P450 3A (CYP3A) but does not alter Lopinavir-Ritonavir Exposure in Healthy Subjects. Pharmacotherapy. 2010 Aug; 30(8): 797–805.

– Soon S, Crawford RI. Recurrent erythema nodosum associated with echinacea herbal therapy. J. 2001;44(2):298–299. / 1683.

– Steinmuller C, Roesler J, Grottrup E et al. Polysaccharides isolated from plant cell cultures of Echinacea purpurea enhance the resistance of immunosuppressed mice against systemic infections with Candida albicans and Listeria monocytogenes. Int J Immunopharmacol 1993;15:605-614.

– Womble D, Helderman JH. Enhancement of allo-responsiveness of human lymphocytes by acemannan (Carrisyn). Int J Immunopharmacol 1988;10:967-974.

– Yale, S. H. and Liu, K. Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trial. Arch.Intern.Med. 7-14-2004;164(11):1237-1241.

– Yale SH, Glurich I. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6,and 2C9. J Altern Complement Med 2005;11:433-439.

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